The TX Retinalsome has a clinically verified 0.00 irritation index from human trials, making it suitable even for sensitive skin types. However, because it contains an active retinoid, some users may experience a brief adjustment period with mild tingling during the first few applications—this is normal and typically resolves within 3-5 days. If you have very sensitive skin, we recommend starting with every-other-night application for the first week, then gradually increasing to nightly use as your skin acclimates. The liposome encapsulation technology significantly reduces irritation compared to traditional retinol products, and the formula is free from common irritants like fragrance, alcohol, and essential oils.

While the formula can be used morning or night, we strongly recommend nighttime application as your primary routine. Retinoids increase photosensitivity, meaning your skin becomes more vulnerable to UV damage when exposed to sunlight. If you choose to use it during your morning routine, you must apply broad-spectrum SPF 30+ sunscreen afterward without exception. Most users find nighttime application more convenient since it eliminates sun protection concerns and allows the active ingredients to work uninterrupted during your skin's natural overnight repair cycle, when cellular regeneration is at its peak.

Each 40ml (1.4 fl oz) tube contains approximately 60-80 applications when used as directed, translating to roughly 2-3 months of daily nighttime use for most users. The dual-chamber dispenser is engineered to release a precisely calibrated amount with each press—enough to cover both under-eye areas without waste. We recommend using a rice-grain-sized amount per eye; more product doesn't accelerate results and may lead to unnecessary waste. For optimal cost-effectiveness and consistent results, establish a nightly routine and avoid over-application.

Most premium eye creams fail to deliver because they contain insufficient concentrations of active ingredients (often less than 1% to minimize irritation risks) or use unstable formulations where ingredients degrade rapidly after manufacturing. The TX Retinalsome addresses both issues: it contains pharmaceutical-grade concentrations (3.5% tranexamic acid, 0.05% retinalsome) that are clinically proven effective, and the dual-chamber technology prevents degradation by keeping reactive ingredients separated until application. Additionally, the liposomal delivery system ensures ingredients actually penetrate to target depths rather than sitting on the skin surface. This combination of high-potency actives, stability-preserving packaging, and enhanced penetration explains why users report results in days rather than the weeks or months required by conventional formulations—or the complete lack of results from degraded products.

Retinalsome is an advanced liposome-encapsulated form of retinaldehyde, which sits one conversion step closer to retinoic acid (the active form) compared to standard retinol, making it significantly more potent. While retinol requires two enzymatic conversions to become active in skin cells, retinalsome requires only one, resulting in up to 11 times faster absorption and more immediate anti-aging effects. The liposome encapsulation provides two critical advantages: it protects the retinoid from degradation before reaching target cells, and it enables time-released delivery that maintains therapeutic concentrations while minimizing surface irritation. This technology allows the TX Retinalsome to deliver prescription-strength results with over-the-counter tolerability—the best of both worlds for wrinkle reduction and collagen stimulation.